Showing posts with label ms. Show all posts
Showing posts with label ms. Show all posts

Monday, December 14, 2009

Experimental Autoimmune Encephalomyelitis (EAE)


Dear Readers,

This post is a discussion on Experimental Autoimmune Encephalomyelitis (EAE) between Dr. Betty Wedman, a Licensed Nutritionist & Environmental Health Specialist. In his response, Dr. Cordain refers to the paper "A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies," which is available for download from our web site.

Dr. Cordain,

As a nutrition instructor at 2 Tampa Bay universities, I include the Paleo Diet in my lesson plans frequently and even considering a Nutrition & Anthropology class option. I would like to have more information about the EAE disease study you mentioned at the American Nutraceutical Association Conference 2009.

Thank you.
Betty Wedman


Hi Betty,

Many thanks for your support of my work. I'm sorry that we didn't get to speak to one another directly at the conference. I'm not completely clear on which study I may have mentioned, but I believe it is a study in which EAE (the animal model of MS) was elicited via vaccination with MOG (myelin oligodendrocyte glycoprotein; a known autoantigen in MS) and Quil A as the adjuvant. Quil A is derived from Quillaja, a saponin derived from the bark of a S. American tree and which is a commonly used additive in root beer and soft drinks to make them foam. My point was that the concentration of Quil A used in the mouse study can be achieved via consumption of root beer and that resident E. Coli contain an epitope similar in structure to MOG. Hence it may be possible to elicit autoimmune diseases via unintentionally mucosal vaccination via certain dietary adjuvants (saponins) in naturally occurring foods along with mimicking epitopes derived from resident gut flora. Attached is the EAE paper.

Cordially,
Loren Cordain, Ph.D., Professor

Wednesday, November 18, 2009

Paleo Diet Q & A - 11.18.09


Dear Readers,

Here's today's edition of Q & A from the Paleo Diet community. Thanks to those of you who've left questions and comments in reply to these posts. Our team is currently reviewing all outstanding questions and will have answers to post soon.



Q: My question is regarding the consumption of milk. There are a great number of coaches around the country who advocate at least moderate, if not generous, amounts of milk in their athletes' diets. Does it not provide a good source of protein and carbohydrate balance, not to mention the calcium content? What is the paleo stance on milk and why?

A: There are several reasons why not to consume dairy products:

Hominids evolved during 2.6 million years behaving as hunter-gatherers.

Although there wasn’t a single diet, and diet rather varied by latitude, season, climate, culture, etc., all ancestral diets shared key characteristics. Food sources were limited to unprocessed foraged plants, and unprocessed land and marine animals hunted from the proximate environment. As such, human diets consisted of combinations of wild animal carcasses (including brains, bone marrow, and organs), shellfish, fish, fruits, leafy vegetables, mushrooms, insects, larvae, nuts, seasonal honey, and eggs.

Ten thousand years ago, major changes in the environment happened, including the human diet. New foods, such as cereal grains, legumes, dairy, vegetable oils, refined sugars, fatty domesticated meats and salt, were introduced.

Since that time, there is strong evidence that our genome has remained essentially unchanged over the past 10,000 years. Evolutionary medicine predicts that these environmental changes may have caused adverse effects.

Indeed, it is believed that this mismatch between our ancient genome and the modern environment (including our modern diet) is at the root of the so-called diseases of western civilization, such as type 2 diabetes, obesity, dislipidemia, hypertension, certain types of cancer, acne, autoimmune diseases, myopia, polycystic ovary syndrome and more.

Regarding dairy, we know that this food group was not available for human intake prior to the onset of animal husbandry--roughly 9,000 years ago in the Middle East, and 7,000 years ago in Northern Europe. So dairy is a relatively new food on an evolutionary time scale, which explains why it may produce the following adverse effects, through different mechanisms:
  • Milk is a source of estrogens and dihydrotestosterone precursors, which can increase the risk of certain cancers and acne.
  • Milk increases IGF-1, and the IGF-1/IGFBP-3 ratio, and this increases the risk of certain cancers and acne--among other diseases--as explained by Dr. Cordain in his 2003 paper “Hyperinsulinemic diseases of civilization: more than just syndrome X” (http://www.thepaleodiet.com/articles/Hyperinsulinemic%20Diseases%20Final.pdf)
  • Milk contains insulin, and bovine insulin differs in only 3 amino acids from human insulin. This feature can increase the risk of Type 1 diabetes in genetically susceptible persons.
  • Betacellulin: is a hormone belonging to the EGF family of hormones. If it is confirmed that Betacellulin is able to enter circulation, then there is a very good possibility that it may increase the susceptibility of certain epithelial cancers.
  • Milk elevates insulin as much as white bread. Constantly elevating plasma insulin levels may lead to insulin resistance, which is at the root of several metabolic diseases such as obesity, type 2 diabetes or hypertension.
  • High calcium intake adversely affects zinc absorption, a key mineral in more than 300 enzymatic reactions.
  • Milk contains several allergenic proteins.
  • Dairy products, especially hard cheeses, yield a very high net acidic load which might lead to calcium and muscle loss and decrease growth hormone.
In sports nutrition BCAA intake is crucial for muscle recovery. Lean meat is the biggest sources of BCAA (33 grs/1000Kcal). Dairy contains much less BCAA (12 grs/1000Kcal), so if you replace lean meats with dairy you are taking much less BCAA which is crucial in muscle recovery.



Q: I was diagnosed with ulcerative colitis about 3 years ago. It started off as a very mild case but recently progressed to the point where my doctor was discussing having my colon removed if a new medication (Remicade) did not work. Being on Remicade has helped, and I was able to put 20 pounds back on. However, I do not believe in medication alone. I believe that diet is a key component to living a healthy life. I follow the Paleo Diet which has helped tremendously. I know that there are certain foods like night shade vegetables, which are part of the Paleo Diet, that I should avoid. Is there any other foods on the Paleo Diet that I should eliminate?

A: Yes, autoimmune patients should make some changes regarding The Paleo Diet:
  • Nightshade (potatoes, eggplants, peppers and tomatoes) should be removed from your diet as they contain harmful lectins and saponins.
  • Egg white is a source of a membranolytic (breaks cell membranes) protein--namely Lisozyme--and therefore should also be removed from your diet.
  • Remember that soy beans derived products, as well as peanuts, are legumes. They should be removed from your diet.
  • Another harmful nutrients are quinoa, amaranth and root beer.
You can find more info in our "How to Treat MS with Diet" program, which is available from our website: http://www.thepaleodiet.com/store.shtml.